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Brief Communication

Nature Genetics 41, 166–167 (1 February 2009) | doi:10.1038/ng.308

System-wide molecular evidence for phenotypic buffering in Arabidopsis

Jingyuan Fu , Joost J B Keurentjes , Harro Bouwmeester , Twan America , Francel W A Verstappen , Jane L Ward , Michael H Beale , Ric C H de Vos , Martijn Dijkstra , Richard A Scheltema , Frank Johannes , Maarten Koornneef , Dick Vreugdenhil , Rainer Breitling & Ritsert C Jansen

We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits.