News and Views
Nature Genetics 41, 141 - 142 (2009)
doi:10.1038/ng0209-141
Hair lost in translation
Lorin Weiner1 & Janice L Brissette1
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Lorin Weiner and Janice L. Brissette are at the Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA. e-mail: lorin.weiner@cbrc2.mgh.harvard.edu
e-mail: janice.brissette@cbrc2.mgh.harvard.edu
Abstract
A new study identifies mutations in the HR gene as the cause of Marie Unna hereditary hypotrichosis (MUHH). The mutations seem to disrupt an unusual leader sequence–based mechanism of translational repression, making MUHH the first example of a disease linked to this form of repression.
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RESEARCH
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosisNature Genetics Letter (01 Feb 2009)
