Brief Communication abstract


Nature Genetics 41, 157 - 159 (2009)
Published online: 18 January 2009 | doi:10.1038/ng.301

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

David Meyre1, Jérôme Delplanque1, Jean-Claude Chèvre1, Cécile Lecoeur1, Stéphane Lobbens1, Sophie Gallina1, Emmanuelle Durand1, Vincent Vatin1, Franck Degraeve1, Christine Proença1, Stefan Gaget1, Antje Körner2, Peter Kovacs3, Wieland Kiess2, Jean Tichet4, Michel Marre5, Anna-Liisa Hartikainen6, Fritz Horber7, Natascha Potoczna7, Serge Hercberg8, Claire Levy-Marchal9, François Pattou10, Barbara Heude11, Maithé Tauber12, Mark I McCarthy13,14,15, Alexandra I F Blakemore16, Alexandre Montpetit17, Constantin Polychronakos17, Jacques Weill18, Lachlan J M Coin19, Julian Asher16, Paul Elliott19, Marjo-Riitta Järvelin19,20, Sophie Visvikis-Siest21, Beverley Balkau11, Rob Sladek17, David Balding19, Andrew Walley16, Christian Dina1 & Philippe Froguel1,16

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We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 times 10-7), near MAF (encoding the transcription factor c-MAF, P = 3.8 times 10-13) and near PTER (phosphotriesterase-related gene, P = 2.1 times 10-7).

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  1. CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
  2. University Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
  3. Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany.
  4. Institut Inter Régional pour la Santé, 37521 La Riche, France.
  5. Department of Endocrinology, Diabetology, Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, 75018 Paris, France, and Institut National de la Santé et de la Recherche Médicale U695, Université Paris 7, 75007 Paris, France.
  6. Department of Clinical Sciences/ Obstetrics and Gynecology, University of Oulu, University of Oulu, 90014 Oulu, Finland.
  7. Klinik Lindberg, 8400 Winterthur, and University of Berne, 3012 Berne, Switzerland.
  8. Unité Mixte de Recherche U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Conservatoire National des arts et Métiers, Université Paris 13, Centre de Recherches en Nutrition Humaine Ile de France, F-93017 Bobigny, France.
  9. Institut National de la Santé et de la Recherche Médicale, U690, Paris, FR-75019, France and Université Paris Diderot, Paris, FR-75205 cedex 13, France.
  10. Institut National de la Santé et de la Recherche Médicale U859, Centre Hospitalier Régional Universitaire de Lille, Lille North of France University, 59000 Lille France.
  11. Institut National de la Santé et de la Recherche Médicale U780, Villejuif, F-94807; University Paris-Sud, Orsay, F-91405, France.
  12. Institut National de la Santé et de la Recherche Médicale U563, Children's Hospital, Centre Hospitalier Universitaire 31000 Toulouse, France.
  13. Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, OX3 7LJ Oxford, UK.
  14. Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 Oxford, UK.
  15. Oxford National Institute for Health Research Biomedical Research Centre, OX3 Oxford, UK.
  16. Section of Genomic Medicine, Hammersmith Hospital, Imperial College London, W12 0HS London, UK.
  17. McGill University and Genome Quebec Innovation Centre, H3A 1A Montreal, Canada.
  18. Pediatric Endocrine Unit, Jeanne de Flandre Hospital, 59000 Lille, France.
  19. Department of Epidemiology and Public Health, Imperial College London, WC1E 6BT London UK.
  20. Institute of Health Sciences, University of Oulu, Department of Child and Adolescent Health, National Public Health Institute, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.
  21. Institut National de la Santé et de la Recherche Médicale "Cardiovascular Genetics" team, Centre D'investigation Clinique 54000 Nancy, France.

Correspondence to: Philippe Froguel1,16 e-mail: p.froguel@imperial.ac.uk