Letter abstract
Nature Genetics 41, 251 - 257 (2009)
Published online: 11 January 2009 | doi:10.1038/ng.289
Experimental evolution reveals natural selection on standing genetic variation
Henrique Teotónio1,
Ivo M Chelo1,
Martina Bradi
2,
Michael R Rose3
&
Anthony D Long3
Evolution depends on genetic variation generated by mutation or recombination from standing genetic variation. In sexual organisms, little is known about the molecular population genetics of adaptation and reverse evolution1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11. We carry out 50 generations of experimental reverse evolution in populations of Drosophila melanogaster, previously differentiated by forward evolution, and follow changes in the frequency of SNPs in both arms of the third chromosome. We characterize the effects of sampling finite population sizes and natural selection at the genotype level. We demonstrate that selection has occurred at several loci and further that there is no general loss or gain of allele diversity. We also observe that despite the complete convergence to ancestral levels of adaptation, allele frequencies only show partial return.
- Instituto Gulbenkian de Ciência, Apartado 14, P-2781-901 Oeiras, Portugal.
- Department of Biology, New York University, New York, New York 10003, USA.
- Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA.
Correspondence to: Henrique Teotónio1 e-mail: teotonio@igc.gulbenkian.pt
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