News and Views
Nature Genetics 41, 1164 - 1166 (2009)
doi:10.1038/ng1109-1164
DNA methylation is a guardian of stem cell self-renewal and multipotency
Laurraine-Marcelle Gereige1 & Hanna K A Mikkola1
- Laurraine-Marcelle Gereige and Hanna K.A. Mikkola are at the Department of Molecular, Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA.
Correspondence to: Hanna K A Mikkola1 e-mail: hmikkola@mcdb.ucla.edu
Abstract
Epigenetic marks, such as DNA methylation and histone modifications, undergo dynamic changes during cellular differentiation and development. A new study demonstrates that DNA methylation by Dnmt1 protects essential stem cell properties in both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) by silencing differentiation programs that interfere with self-renewal and multipotency.
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