Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Nature Genetics volume 41, pages 1055–1057 (2009)Cite this article

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10−10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: LD structure and regional association results for 82 SNPs genotyped over ∼314 kb of chromosome 8q24.

Similar content being viewed by others

References

  1. Amundadottir, L.T. et al. Nat. Genet. 38, 652–658 (2006).

    Article  CAS  Google Scholar 

  2. Freedman, M.L. et al. Proc. Natl. Acad. Sci. USA 103, 14068–14073 (2006).

    Article  CAS  Google Scholar 

  3. Gudmundsson, J. et al. Nat. Genet. 39, 631–637 (2007).

    Article  CAS  Google Scholar 

  4. Haiman, C.A. et al. Nat. Genet. 39, 638–644 (2007).

    Article  CAS  Google Scholar 

  5. Thomas, G. et al. Nat. Genet. 40, 310–315 (2008).

    Article  CAS  Google Scholar 

  6. Easton, D.F. et al. Nature 447, 1087–1093 (2007).

    Article  CAS  Google Scholar 

  7. Haiman, C.A. et al. Nat. Genet. 39, 954–956 (2007).

    Article  CAS  Google Scholar 

  8. Zanke, B.W. et al. Nat. Genet. 39, 989–994 (2007).

    Article  CAS  Google Scholar 

  9. Tomlinson, I. et al. Nat. Genet. 39, 984–988 (2007).

    Article  CAS  Google Scholar 

  10. Kiemeney, L.A. et al. Nat. Genet. 40, 1307–1312 (2008).

    Article  CAS  Google Scholar 

  11. Pomerantz, M.M. et al. Nat. Genet. 41, 882–884 (2009).

    Article  CAS  Google Scholar 

  12. Witte, J.S. Nat. Genet. 39, 579–580 (2007).

    Article  CAS  Google Scholar 

  13. Ghoussaini, M. et al. J. Natl. Cancer Inst. 100, 962–966 (2008).

    Article  CAS  Google Scholar 

  14. Berndt, S.I. et al. Hum. Mol. Genet. 17, 2665–2672 (2008).

    Article  CAS  Google Scholar 

  15. Wokolorczyk, D. et al. Cancer Res. 68, 9982–9986 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This project was funded in part using grants CA129684 to J.X. and CA131338 to S.L.Z. This project was funded in whole or in part with federal funds from the NCI, National Institutes of Health (NIH), under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (DHHS), nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

Author information

Authors and Affiliations

  1. Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA

    Meredith Yeager, Amy Hutchinson & Zhaoming Wang

  2. Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, USA

    Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Jesus Gonzalez-Bosquet, Richard B Hayes, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Demetrius Albanes, Stephanie Weinstein, Margaret Tucker, Robert N Hoover, Joseph F Fraumeni Jr, Gilles Thomas & Stephen J Chanock

  3. Bioinformed Consulting Services, Gaithersburg, Maryland, USA

    Kevin B Jacobs

  4. Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Peter Kraft, Fredrick R Schumacher & David J Hunter

  5. Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA

    Heather Spencer Feigelson, Michael J Thun & W Ryan Diver

  6. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    Jarmo Virtamo

  7. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA

    Fredrick R Schumacher

  8. Centre de Recherche pour les Pathologies Prostatiques (CeRePP), Hôpital Tenon, Assistance Publique–Hôpitaux de Paris, Paris, France

    Geraldine Cancel-Tassin, Olivier Cussenot & Antoine Valeri

  9. Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

    Gerald L Andriole

  10. Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA

    E David Crawford

  11. Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA

    Christopher A Haiman & Brian Henderson

  12. Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA

    Laurence Kolonel & Loic Le Marchand

  13. Division of Epidemiology, Public Health and Primary Care, Imperial College, London, England

    Afshan Siddiq & Elio Riboli

  14. Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom

    Timothy J Key

  15. Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany

    Rudolf Kaaks

  16. Johns Hopkins Hospital, Baltimore, Maryland, USA

    William Isaacs, Sarah Isaacs & Kathleen E Wiley

  17. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Henrik Gronberg & Fredrik Wiklund

  18. Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden

    Pär Stattin

  19. Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

    Jianfeng Xu, S Lilly Zheng & Jielin Sun

  20. Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

    Lars J Vatten & Kristian Hveem

  21. Institute of Community Medicine, University of Tromsø, Tromsø, Norway

    Merethe Kumle

  22. Office of Cancer Genomics, NCI, NIH, DHHS, Bethesda, Maryland, USA

    Daniela S Gerhard

  23. Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    David J Hunter

Authors
  1. Meredith Yeager
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nilanjan Chatterjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Julia Ciampa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kevin B Jacobs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jesus Gonzalez-Bosquet
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Richard B Hayes
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Peter Kraft
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sholom Wacholder
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Nick Orr
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sonja Berndt
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kai Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Amy Hutchinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Zhaoming Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Laufey Amundadottir
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Heather Spencer Feigelson
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Michael J Thun
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. W Ryan Diver
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Demetrius Albanes
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Jarmo Virtamo
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Stephanie Weinstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Fredrick R Schumacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Geraldine Cancel-Tassin
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Olivier Cussenot
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Antoine Valeri
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Gerald L Andriole
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. E David Crawford
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Christopher A Haiman
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Brian Henderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Laurence Kolonel
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Loic Le Marchand
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Afshan Siddiq
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Elio Riboli
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Timothy J Key
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Rudolf Kaaks
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. William Isaacs
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Sarah Isaacs
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. Kathleen E Wiley
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. Henrik Gronberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. Fredrik Wiklund
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. Pär Stattin
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. Jianfeng Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. S Lilly Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. Jielin Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. Lars J Vatten
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. Kristian Hveem
    View author publications

    You can also search for this author in PubMed Google Scholar

  46. Merethe Kumle
    View author publications

    You can also search for this author in PubMed Google Scholar

  47. Margaret Tucker
    View author publications

    You can also search for this author in PubMed Google Scholar

  48. Daniela S Gerhard
    View author publications

    You can also search for this author in PubMed Google Scholar

  49. Robert N Hoover
    View author publications

    You can also search for this author in PubMed Google Scholar

  50. Joseph F Fraumeni Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  51. David J Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  52. Gilles Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

  53. Stephen J Chanock
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

M.Y., N.C. and S.J.C. drafted the manuscript; N.C., J.C., K.B.J., Z.W. and M.Y. performed statistical analyses; K.B.J., N.C., J.G.-B., P.K., S.W., N.O., K.Y. and L.A. made important suggestions to the analytic plan and/or aided interpretation of results; A.H. led the genotyping efforts; R.B.H., S.B., H.S.F., M.J.T., W.R.D., D.A., J.V., S.W., F.R.S., G.C.-T., O.C., A.V., G.L.A., E.D.C., C.A.H., B.H., L.K., L.L.M., A.S., E.R., T.J.K., R.K., W.I., S.I., K.E.W., H.G., F.W., P.S., J.X., S.L.Z., J.S., L.J.V., K.H. and M.K. provided DNA or genotyping data for study subjects; M.T., D.S.G., R.N.H., J.F.F., D.J.H. and G.T. participated in revising the manuscript and provided important intellectual contributions.

Corresponding author

Correspondence to Meredith Yeager.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1 and 2, Supplementary Tables 1–5 and Supplementary Methods. (PDF 534 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yeager, M., Chatterjee, N., Ciampa, J. et al. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet 41, 1055–1057 (2009). https://doi.org/10.1038/ng.444

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.444

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing