Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes.
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Owens, D. Tcf proteins are deeply rooted in skin. Nat Genet 41, 1050–1051 (2009). https://doi.org/10.1038/ng1009-1050
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DOI: https://doi.org/10.1038/ng1009-1050
