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Brief Communication

Nature Genetics 41, 1058–1060 (1 October 2009) | doi:10.1038/ng.452

Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama , Zsofia Kote-Jarai , Graham G Giles , Michelle Guy , Jonathan Morrison , Gianluca Severi , Daniel A Leongamornlert , Malgorzata Tymrakiewicz , Sameer Jhavar , Ed Saunders , John L Hopper , Melissa C Southey , Kenneth R Muir , Dallas R English , David P Dearnaley , Audrey T Ardern-Jones , Amanda L Hall , Lynne T O'Brien , Rosemary A Wilkinson , Emma Sawyer , Artitaya Lophatananon , Alan Horwich , Robert A Huddart , Vincent S Khoo , Christopher C Parker , Christopher J Woodhouse , Alan Thompson , Tim Christmas , Chris Ogden , Colin Cooper , Jenny L Donovan , Freddie C Hamdy , David E Neal , Rosalind A Eeles & Douglas F Easton

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls.