Data producers deserve citation credit - p1045

doi:10.1038/ng1009-1045

Abstract - Data producers deserve citation credit | Full Text - Data producers deserve citation credit | PDF (80 KB) - Data producers deserve citation credit

Alzheimer's disease beyond APOE - pp1047 - 1048

Michael A van Es & Leonard H van den Berg

doi:10.1038/ng1009-1047

Abstract - Alzheimer/'s disease beyond APOE | Full Text - Alzheimer's disease beyond APOE | PDF (239 KB) - Alzheimer's disease beyond APOE

See also: Letter by Harold et al. | Letter by Lambert et al.

Interferon-alfa, interferon- and hepatitis C - pp1048 - 1050

Thomas R O'Brien

doi:10.1038/ng.453

Abstract - Interferon-alfa, interferon-[lambda] and hepatitis C | Full Text - Interferon-alfa, interferon- and hepatitis C | PDF (421 KB) - Interferon-alfa, interferon- and hepatitis C

See also: Letter by Suppiah et al. | Letter by Tanaka et al.

Tcf proteins are deeply rooted in skin - pp1050 - 1051

David M Owens

doi:10.1038/ng1009-1050

Abstract - Tcf proteins are deeply rooted in skin | Full Text - Tcf proteins are deeply rooted in skin | PDF (610 KB) - Tcf proteins are deeply rooted in skin

See also: Article by Nguyen et al.

Research highlights - p1052

doi:10.1038/ng1009-1052

Full Text - Research highlights | PDF (74 KB) - Research highlights

Identification of a new prostate cancer susceptibility locus on chromosome 8q24 - pp1055 - 1057

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S Lilly Zheng, Jielin Sun, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S Gerhard, Robert N Hoover, Joseph F Fraumeni Jr, David J Hunter, Gilles Thomas & Stephen J Chanock

doi:10.1038/ng.444

Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which shows association to prostate cancer susceptibility independent of previously reported associations at 8q24.

Abstract - Identification of a new prostate cancer susceptibility locus on chromosome 8q24 | Full Text - Identification of a new prostate cancer susceptibility locus on chromosome 8q24 | PDF (234 KB) - Identification of a new prostate cancer susceptibility locus on chromosome 8q24 | Supplementary information

Multiple loci on 8q24 associated with prostate cancer susceptibility - pp1058 - 1060

Ali Amin Al Olama, Zsofia Kote-Jarai, Graham G Giles, Michelle Guy, Jonathan Morrison, Gianluca Severi, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders, John L Hopper, Melissa C Southey, Kenneth R Muir, Dallas R English, David P Dearnaley, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Emma Sawyer, Artitaya Lophatananon, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind A Eeles & Douglas F Easton

doi:10.1038/ng.452

Douglas Easton and colleagues report a comprehensive analysis of SNP associations to prostate cancer across the 8q24 region. They report 8 SNPs in 5 blocks independently associated to prostate cancer risk.

Abstract - Multiple loci on 8q24 associated with prostate cancer susceptibility | Full Text - Multiple loci on 8q24 associated with prostate cancer susceptibility | PDF (324 KB) - Multiple loci on 8q24 associated with prostate cancer susceptibility | Supplementary information

Personalized copy number and segmental duplication maps using next-generation sequencing - pp1061 - 1067

Can Alkan, Jeffrey M Kidd, Tomas Marques-Bonet, Gozde Aksay, Francesca Antonacci, Fereydoun Hormozdiari, Jacob O Kitzman, Carl Baker, Maika Malig, Onur Mutlu, S Cenk Sahinalp, Richard A Gibbs & Evan E Eichler

doi:10.1038/ng.437

Evan Eichler and colleagues have developed an algorithm called mrFAST to map short, next-generation sequence reads across the genome that allows for the accurate prediction of copy-number variation.

Abstract - Personalized copy number and segmental duplication maps using next-generation sequencing | Full Text - Personalized copy number and segmental duplication maps using next-generation sequencing | PDF (794 KB) - Personalized copy number and segmental duplication maps using next-generation sequencing | Supplementary information

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia - pp1068 - 1075

Hoang Nguyen, Bradley J Merrill, Lisa Polak, Maria Nikolova, Michael Rendl, Timothy M Shaver, H Amalia Pasolli & Elaine Fuchs

doi:10.1038/ng.431

Elaine Fuchs and colleagues present mice conditionally lacking Tcf3 and Tcf4 in the skin and show that they play a role in long-term maintenance and wound repair of both epidermis and hair follicles.

Abstract - Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia | Full Text - Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia | PDF (1,490 KB) - Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia | Supplementary information

See also: News and Views by Owens

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling - pp1076 - 1082

Anne-Marie Martinez, Bernd Schuettengruber, Samy Sakr, Ana Janic, Cayetano Gonzalez & Giacomo Cavalli

doi:10.1038/ng.414

Giacomo Cavalli and colleagues report that the polycomb gene polyhomeotic acts as a tumor suppressor in the Drosophila eye by repressing the Notch signaling pathway.

Abstract - Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling | Full Text - Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling | PDF (1,553 KB) - Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling | Supplementary information

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis - pp1083 - 1087

Michael A van Es, Jan H Veldink, Christiaan G J Saris, Hylke M Blauw, Paul W J van Vught, Anna Birve, Robin Lemmens, Helenius J Schelhaas, Ewout J N Groen, Mark H B Huisman, Anneke J van der Kooi, Marianne de Visser, Caroline Dahlberg, Karol Estrada, Fernando Rivadeneira, Albert Hofman, Machiel J Zwarts, Perry T C van Doormaal, Dan Rujescu, Eric Strengman, Ina Giegling, Pierandrea Muglia, Barbara Tomik, Agnieszka Slowik, Andre G Uitterlinden, Corinna Hendrich, Stefan Waibel, Thomas Meyer, Albert C Ludolph, Jonathan D Glass, Shaun Purcell, Sven Cichon, Markus M Nöthen, H-Erich Wichmann, Stefan Schreiber, Sita H H M Vermeulen, Lambertus A Kiemeney, John H J Wokke, Simon Cronin, Russell L McLaughlin, Orla Hardiman, Katsumi Fumoto, R Jeroen Pasterkamp, Vincent Meininger, Judith Melki, P Nigel Leigh, Christopher E Shaw, John E Landers, Ammar Al-Chalabi, Robert H Brown Jr, Wim Robberecht, Peter M Andersen, Roel A Ophoff & Leonard H van den Berg

doi:10.1038/ng.442

Leonard van den Berg, Roel Ophoff and colleagues present a genome-wide association study of sporadic amyotrophic lateral sclerosis. The work uncovers associated SNPs at 9p21.2 and an associated locus at 19p13.3 mapping to the UNC13A gene.

First Paragraph - Genome-wide association study identifies 19p13.3 (: UNC13A: ) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis | Full Text - Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis | PDF (522 KB) - Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis | Supplementary information

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease - pp1088 - 1093

Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams, Nicola Jones, Charlene Thomas, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, John Hardy, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Kristel Sleegers, Karolien Bettens, Sebastiaan Engelborghs, Peter P De Deyn, Christine Van Broeckhoven, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panagiotis Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Magda Tsolaki, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, Peter A Holmans, Michael O'Donovan, Michael J Owen & Julie Williams

doi:10.1038/ng.440

Julie Williams and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants at the CLU and PICALM loci associated with susceptibility to late-onset Alzheimer's disease.

First Paragraph - Genome-wide association study identifies variants at : CLU: and : PICALM: associated with Alzheimer's disease | Full Text - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | PDF (498 KB) - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Supplementary information

See also: News and Views by van Es & van den Berg | Letter by Lambert et al.

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease - pp1094 - 1099

Jean-Charles Lambert, Simon Heath, Gael Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Diana Zelenika, Maria J Bullido, Béatrice Tavernier, Luc Letenneur, Karolien Bettens, Claudine Berr, Florence Pasquier, Nathalie Fiévet, Pascale Barberger-Gateau, Sebastiaan Engelborghs, Peter De Deyn, Ignacio Mateo, Ana Franck, Seppo Helisalmi, Elisa Porcellini, Olivier Hanon, the European Alzheimer's Disease Initiative Investigators, Marian M de Pancorbo, Corinne Lendon, Carole Dufouil, Céline Jaillard, Thierry Leveillard, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Paola Piccardi, Giorgio Annoni, Davide Seripa, Daniela Galimberti, Didier Hannequin, Federico Licastro, Hilkka Soininen, Karen Ritchie, Hélène Blanché, Jean-François Dartigues, Christophe Tzourio, Ivo Gut, Christine Van Broeckhoven, Annick Alpérovitch, Mark Lathrop & Philippe Amouyel

doi:10.1038/ng.439

Philippe Amouyel and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants within CLU and CR1 associated with susceptibility to late-onset Alzheimer's disease.

First Paragraph - Genome-wide association study identifies variants at : CLU: and : CR1: associated with Alzheimer's disease | Full Text - Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | PDF (640 KB) - Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Supplementary information

See also: News and Views by van Es & van den Berg | Letter by Harold et al.

IL28B is associated with response to chronic hepatitis C interferon- and ribavirin therapy - pp1100 - 1104

Vijayaprakash Suppiah, Max Moldovan, Golo Ahlenstiel, Thomas Berg, Martin Weltman, Maria Lorena Abate, Margaret Bassendine, Ulrich Spengler, Gregory J Dore, Elizabeth Powell, Stephen Riordan, David Sheridan, Antonina Smedile, Vincenzo Fragomeli, Tobias Müller, Melanie Bahlo, Graeme J Stewart, David R Booth & Jacob George for the Hepatitis C Study

doi:10.1038/ng.447

Jacob George and colleagues report a genome-wide association study to hepatitis C treatment response. They report an association of common variants within the IL28B region to sustained virologic response following pegylated interferon alpha and ribavirin combined therapy in individuals with genotype 1 chronic hepatitis C.

First Paragraph - IL28B: is associated with response to chronic hepatitis C interferon-[alpha] and ribavirin therapy | Full Text - IL28B is associated with response to chronic hepatitis C interferon- and ribavirin therapy | PDF (378 KB) - IL28B is associated with response to chronic hepatitis C interferon- and ribavirin therapy | Supplementary information

See also: News and Views by O'Brien | Letter by Tanaka et al.

Genome-wide association of IL28B with response to pegylated interferon- and ribavirin therapy for chronic hepatitis C - pp1105 - 1109

Yasuhito Tanaka, Nao Nishida, Masaya Sugiyama, Masayuki Kurosaki, Kentaro Matsuura, Naoya Sakamoto, Mina Nakagawa, Masaaki Korenaga, Keisuke Hino, Shuhei Hige, Yoshito Ito, Eiji Mita, Eiji Tanaka, Satoshi Mochida, Yoshikazu Murawaki, Masao Honda, Akito Sakai, Yoichi Hiasa, Shuhei Nishiguchi, Asako Koike, Isao Sakaida, Masatoshi Imamura, Kiyoaki Ito, Koji Yano, Naohiko Masaki, Fuminaka Sugauchi, Namiki Izumi, Katsushi Tokunaga & Masashi Mizokami

doi:10.1038/ng.449

Masashi Mizokami and colleagues report a genome-wide association study to hepatitis C treatment response in two Japanese cohorts. They report common variants at IL28B associated with sustained as well as null virologic response following pegylated interferon-alpha and ribavirin combined therapy.

First Paragraph - Genome-wide association of : IL28B: with response to pegylated interferon-[alpha] and ribavirin therapy for chronic hepatitis C | Full Text - Genome-wide association of IL28B with response to pegylated interferon- and ribavirin therapy for chronic hepatitis C | PDF (790 KB) - Genome-wide association of IL28B with response to pegylated interferon- and ribavirin therapy for chronic hepatitis C | Supplementary information

See also: News and Views by O'Brien | Letter by Suppiah et al.

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia - pp1110 - 1115

Johan Rung, Stéphane Cauchi, Anders Albrechtsen, Lishuang Shen, Ghislain Rocheleau, Christine Cavalcanti-Proença, François Bacot, Beverley Balkau, Alexandre Belisle, Knut Borch-Johnsen, Guillaume Charpentier, Christian Dina, Emmanuelle Durand, Paul Elliott, Samy Hadjadj, Marjo-Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander Mazur, David Meyre, Alexandre Montpetit, Charlotta Pisinger, Barry Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel-Madsen, Aimo Ruokonen, Anelli Sandbaek, David Serre, Jean Tichet, Martine Vaxillaire, Jørgen F P Wojtaszewski, Allan Vaag, Torben Hansen, Constantin Polychronakos, Oluf Pedersen, Philippe Froguel & Robert Sladek

doi:10.1038/ng.443

Rob Sladek and colleagues identify a common variant near the insulin receptor substrate 1 gene (IRS1) associated with type 2 diabetes, insulin resistance, hyperinsulinemia and impaired insulin signaling. This is the first confirmed diabetes risk locus associated with insulin resistance.

First Paragraph - Genetic variant near : IRS1: is associated with type 2 diabetes, insulin resistance and hyperinsulinemia | Full Text - Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia | PDF (377 KB) - Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia | Supplementary information

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study - pp1116 - 1121

Rosalind A Eeles, Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L Hopper, Brian E Henderson, Christopher A Haiman, Johanna Schleutker, Freddie C Hamdy, David E Neal, Jenny L Donovan, Janet L Stanford, Elaine A Ostrander, Sue A Ingles, Esther M John, Stephen N Thibodeau, Daniel Schaid, Jong Y Park, Amanda Spurdle, Judith Clements, Joanne L Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R Rebbeck, Kathleen A Cooney, Lisa Cannon-Albright, Pierre O Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong-Wei Zhang, Yong-Jie Lu, William D Foulkes, Dallas R English, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Edward J Saunders, Elizabeth C Page, Emma J Sawyer, Stephen M Edwards, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas Van As, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S Cooper, Melissa C Southey, Artitaya Lophatananon, Jo-Fen Liu, Laurence N Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L Tammela, Anssi Auvinen, Sarah J Lewis, Angela Cox, Liesel M FitzGerald, Joseph S Koopmeiners, Danielle M Karyadi, Erika M Kwon, Mariana C Stern, Roman Corral, Amit D Joshi, Ahva Shahabi, Shannon K McDonnell, Thomas A Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, R A (Frank) Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M Ray, Ethan M Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, The PRACTICAL Consortium & Douglas F Easton

doi:10.1038/ng.450

Rosalind Eeles and colleagues present a genome-wide association study for prostate cancer. They report seven loci newly associated with prostate cancer susceptibility.

Abstract - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study | Full Text - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study | PDF (386 KB) - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study | Supplementary information

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility - pp1122 - 1126

Julius Gudmundsson, Patrick Sulem, Daniel F Gudbjartsson, Thorarinn Blondal, Arnaldur Gylfason, Bjarni A Agnarsson, Kristrun R Benediktsdottir, Droplaug N Magnusdottir, Gudbjorg Orlygsdottir, Margret Jakobsdottir, Simon N Stacey, Asgeir Sigurdsson, Tiina Wahlfors, Teuvo Tammela, Joan P Breyer, Kate M McReynolds, Kevin M Bradley, Berta Saez, Javier Godino, Sebastian Navarrete, Fernando Fuertes, Laura Murillo, Eduardo Polo, Katja K Aben, Inge M van Oort, Brian K Suarez, Brian T Helfand, Donghui Kan, Carlo Zanon, Michael L Frigge, Kristleifur Kristjansson, Jeffrey R Gulcher, Gudmundur V Einarsson, Eirikur Jonsson, William J Catalona, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Smith, Johanna Schleutker, Rosa B Barkardottir, Augustine Kong, Unnur Thorsteinsdottir, Thorunn Rafnar & Kari Stefansson

doi:10.1038/ng.448

Julius Gudmundsson and colleagues report a prostate cancer genome-wide association follow-on study. They report variants at 3q21.3, 8q24.21 and 19q13.2 newly associated to prostate cancer susceptibility and the fine-mapping of the association signal at 11q13.

Abstract - Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility | Full Text - Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility | PDF (296 KB) - Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility | Supplementary information

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 - pp1127 - 1132

Todd D Prickett, Neena S Agrawal, Xiaomu Wei, Kristin E Yates, Jimmy C Lin, John R Wunderlich, Julia C Cronin, Pedro Cruz, NISC Comparative Sequencing Program, Steven A Rosenberg & Yardena Samuels

doi:10.1038/ng.438

Yardena Samuels and colleagues report a mutational analysis of the protein tyrosine kinase family in cutaneous metastatic melanoma. They find ERBB4 mutations in 19% of tumors and show that these mutations enhance ERBB4 kinase activity and transformation ability, identifying ERBB4 as a potential drug target in melanomas carrying these mutations.

First Paragraph - Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in : ERBB4 | Full Text - Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 | PDF (991 KB) - Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 | Supplementary information

In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression - pp1133 - 1137

Corbin E Meacham, Emily E Ho, Esther Dubrovsky, Frank B Gertler & Michael T Hemann

doi:10.1038/ng.451

Michael Hemann and colleagues report pooled shRNA screening in a mouse model of B cell lymphoma, identifying genes involved in lymphoma progression.

First Paragraph - In vivo: RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression | Full Text - In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression | PDF (494 KB) - In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression | Supplementary information

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice - pp1138 - 1143

Yvonne Begus-Nahrmann, André Lechel, Anna C Obenauf, Kodandaramireddy Nalapareddy, Elvira Peit, Eva Hoffmann, Falk Schlaudraff, Birgit Liss, Peter Schirmacher, Hans Kestler, Esther Danenberg, Nick Barker, Hans Clevers, Michael R Speicher & K Lenhard Rudolph

doi:10.1038/ng.426

K. Lenhard Rudolph and colleagues report that conditional p53 deletion in the intestinal epithelium of aging mice impaired the depletion of chromosomal-instable stem cells and shortened the lifespan of telomere-dysfunctional mice without inducing tumor formation.

First Paragraph - p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice | Full Text - p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice | PDF (948 KB) - p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice | Supplementary information

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53 - pp1144 - 1149

Yaroslava Ruzankina, David W Schoppy, Amma Asare, Carolyn E Clark, Robert H Vonderheide & Eric J Brown

doi:10.1038/ng.441

Eric Brown and colleagues report the mosaic deletion of ATR combined with loss of p53 led to accumulation of highly damaged cells and severe defects in tissue regeneration in adult mice.

First Paragraph - Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of : Atr: and : Trp53 | Full Text - Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53 | PDF (1,456 KB) - Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53 | Supplementary information

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling - pp1150 - 1155

Anne-Kathrin Classen, Brandon D Bunker, Kieran F Harvey, Thomas Vaccari & David Bilder

doi:10.1038/ng.445

David Bilder and colleagues report that the Polycomb repressive complex 1 acts as a tumor suppressor in the Drosophila eye imaginal disc and that this function is mediated by repression of the JAK-STAT signaling pathway.

First Paragraph - A tumor suppressor activity of : Drosophila: Polycomb genes mediated by JAK-STAT signaling | Full Text - A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling | PDF (1,001 KB) - A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling | Supplementary information

Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer - p1156

Xifeng Wu, Yuanqing Ye, Lambertus A Kiemeney, Patrick Sulem, Thorunn Rafnar, Giuseppe Matullo, Daniela Seminara, Teruhiko Yoshida, Norihisa Saeki, Angeline S Andrew, Colin P Dinney, Bogdan Czerniak, Zuo-feng Zhang, Anne E Kiltie, D Timothy Bishop, Paolo Vineis, Stefano Porru, Frank Buntinx, Eliane Kellen, Maurice P Zeegers, Rajiv Kumar, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Jose Ignacio Mayordomo, Manuel Sanchez, Berta Saez, Annika Lindblom, Petra de Verdier, Gunnar Steineck, Gordon B Mills, Alan Schned, Shen-Chih Chang, Jie Lin, David W Chang, Katherine S Hale, Tadeusz Majewski, H Barton Grossman, Steinunn Thorlacius, Unnur Thorsteinsdottir, Katja K H Aben, J Alfred Witjes, Kari Stefansson, Christopher I Amos, Margaret R Karagas & Jian Gu

doi:10.1038/ng1009-1156a

Full Text - Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer | PDF (67 KB) - Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

Erratum: Elucidating the role of 8q24 in colorectal cancer - p1156

Olivier Harismendy & Kelly A Frazer

doi:10.1038/ng1009-1156b

Full Text - Erratum: Elucidating the role of 8q24 in colorectal cancer | PDF (65 KB) - Erratum: Elucidating the role of 8q24 in colorectal cancer

Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia - p1156

Johan Rung, Stéphane Cauchi, Anders Albrechtsen, Lishuang Shen, Ghislain Rocheleau, Christine Cavalcanti-Proença, François Bacot, Beverley Balkau, Alexandre Belisle, Knut Borch-Johnsen, Guillaume Charpentier, Christian Dina, Emmanuelle Durand, Paul Elliott, Samy Hadjadj, Marjo-Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander Mazur, David Meyre, Alexandre Montpetit, Charlotta Pisinger, Barry Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel-Madsen, Aimo Ruokonen, Anelli Sandbaek, David Serre, Jean Tichet, Martine Vaxillaire, Jørgen F P Wojtaszewski, Allan Vaag, Torben Hansen, Constantin Polychronakos, Oluf Pedersen, Philippe Froguel & Robert Sladek

doi:10.1038/ng1009-1156c

Full Text - Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia | PDF (67 KB) - Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease - p1156

Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams, Nicola Jones, Charlene Thomas, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, John Hardy, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich,, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Kristel Sleegers, Karolien Bettens, Sebastiaan Engelborghs, Peter P De Deyn, Christine Van Broeckhoven, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panagiotis Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Magda Tsolaki, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, Peter A Holmans, Michael O'Donovan, Michael J Owen & Julie Williams

doi:10.1038/ng1009-1156d

Full Text - Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | PDF (69 KB) - Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease