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Volume 41 Issue 10, October 2009

Cover Art: Primordial Chronicles #1 by George Fellner from eoartlab (www.eoartlab.com)

Editorial

  • Datasets released to public databases in advance of (or with) research publications should be given digital object identifiers to allow databases and journals to give quantitative citation credit to the data producers and curators.

    Editorial

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News & Views

  • Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.

    • Michael A van Es
    • Leonard H van den Berg
    News & Views
  • Three new studies report genetic variants near IL28B, which encodes interferon-λ3 (interleukin 28B), are associated with response to treatment of chronic hepatitis C virus infection with interferon-alfa/ribavirin combination therapy. This renews interest in how interferons suppress viremia and could lead to improved clinical decisions for chronic HCV infection treatment based on individual genotype.

    • Thomas R O'Brien
    News & Views
  • Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes.

    • David M Owens
    News & Views
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Research Highlights

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Brief Communication

  • Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which shows association to prostate cancer susceptibility independent of previously reported associations at 8q24.

    • Meredith Yeager
    • Nilanjan Chatterjee
    • Stephen J Chanock
    Brief Communication
  • Douglas Easton and colleagues report a comprehensive analysis of SNP associations to prostate cancer across the 8q24 region. They report 8 SNPs in 5 blocks independently associated to prostate cancer risk.

    • Ali Amin Al Olama
    • Zsofia Kote-Jarai
    • Douglas F Easton
    Brief Communication
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Article

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Letter

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Corrigendum

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Erratum

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