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Brief Communication

Nature Genetics 41, 1055–1057 (1 October 2009) | doi:10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager , Nilanjan Chatterjee , Julia Ciampa , Kevin B Jacobs , Jesus Gonzalez-Bosquet , Richard B Hayes , Peter Kraft , Sholom Wacholder , Nick Orr , Sonja Berndt , Kai Yu , Amy Hutchinson , Zhaoming Wang , Laufey Amundadottir , Heather Spencer Feigelson , Michael J Thun , W Ryan Diver , Demetrius Albanes , Jarmo Virtamo , Stephanie Weinstein , Fredrick R Schumacher , Geraldine Cancel-Tassin , Olivier Cussenot , Antoine Valeri , Gerald L Andriole , E David Crawford , Christopher A Haiman , Brian Henderson , Laurence Kolonel , Loic Le Marchand , Afshan Siddiq , Elio Riboli , Timothy J Key , Rudolf Kaaks , William Isaacs , Sarah Isaacs , Kathleen E Wiley , Henrik Gronberg , Fredrik Wiklund , P|[auml]|r Stattin , Jianfeng Xu , S Lilly Zheng , Jielin Sun , Lars J Vatten , Kristian Hveem , Merethe Kumle , Margaret Tucker , Daniela S Gerhard , Robert N Hoover , Joseph F Fraumeni , David J Hunter , Gilles Thomas & Stephen J Chanock

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 |[times]| 10|[minus]|10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45).