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Nature Genetics 41, 1050 - 1051 (2009)
doi:10.1038/ng1009-1050
Tcf proteins are deeply rooted in skin
David M Owens1
- David M. Owens is at the Departments of Dermatology and Pathology, Columbia University, College of Physicians & Surgeons, New York, New York, USA.
Correspondence to: David M Owens1 e-mail: do2112@columbia.edu
Abstract
Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes.
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