Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Alzheimer’s disease beyond APOE

Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The balance between APP processing and clearance in a model of AD pathogenesis.

References

  1. Ferri, C.P. et al. Lancet 366, 2112–2117 (2005).

    Article  Google Scholar 

  2. Blennow, K., de Leon, M.J. & Zetterberg, H. Lancet 368, 387–403 (2006).

    Article  CAS  Google Scholar 

  3. Lambert, J.-C. et al. Nat. Genet. 41, 1094–1099 (2009).

    Article  CAS  Google Scholar 

  4. Harold, D. et al. Nat. Genet. 41, 1088–1093 (2009).

    Article  CAS  Google Scholar 

  5. Goate, A. et al. Nature 349, 704–706 (1991).

    Article  CAS  Google Scholar 

  6. Sherrington, R. et al. Nature 375, 754–760 (1995).

    Article  CAS  Google Scholar 

  7. Levy-Lahad, E. et al. Science 269, 973–977 (1995).

    Article  CAS  Google Scholar 

  8. Corder, E.H. et al. Science 261, 921–923 (1993).

    Article  CAS  Google Scholar 

  9. Corder, E.H. et al. Nat. Genet. 7, 180–184 (1994).

    CAS  Google Scholar 

  10. Waring, S.C. & Rosenberg, R. Arch. Neurol. 65, 329–334 (2008).

    Google Scholar 

  11. Ashford, J.W. & Mortimer, J.A. J. Alzheimers Dis. 4, 169–177 (2002).

    Google Scholar 

  12. Carrasquillo, M.M. et al. Nat. Genet. 41, 192–198 (2009).

    Article  CAS  Google Scholar 

  13. Laurén, J. et al. Nature 457, 1128–1132 (2009).

    Article  Google Scholar 

  14. Nikolaev, A. et al. Nature 457, 981–989 (2009).

    Article  CAS  Google Scholar 

  15. Wyss-Coray, T. et al. Proc. Natl. Acad. Sci. USA 99, 10837–10842 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Michael A van Es or Leonard H van den Berg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Es, M., van den Berg, L. Alzheimer’s disease beyond APOE. Nat Genet 41, 1047–1048 (2009). https://doi.org/10.1038/ng1009-1047

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1009-1047

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing