Brief Communication abstract
Nature Genetics 41, 1055 - 1057 (2009)
Published online: 20 September 2009 | doi:10.1038/ng.444
Identification of a new prostate cancer susceptibility locus on chromosome 8q24
Meredith Yeager1,2, Nilanjan Chatterjee2, Julia Ciampa2, Kevin B Jacobs3, Jesus Gonzalez-Bosquet2, Richard B Hayes2, Peter Kraft4, Sholom Wacholder2, Nick Orr2, Sonja Berndt2, Kai Yu2, Amy Hutchinson1,2, Zhaoming Wang1,2, Laufey Amundadottir2, Heather Spencer Feigelson5, Michael J Thun5, W Ryan Diver5, Demetrius Albanes2, Jarmo Virtamo6, Stephanie Weinstein2, Fredrick R Schumacher4,7, Geraldine Cancel-Tassin8, Olivier Cussenot8, Antoine Valeri8, Gerald L Andriole9, E David Crawford10, Christopher A Haiman11, Brian Henderson11, Laurence Kolonel12, Loic Le Marchand12, Afshan Siddiq13, Elio Riboli13, Timothy J Key14, Rudolf Kaaks15, William Isaacs16, Sarah Isaacs16, Kathleen E Wiley16, Henrik Gronberg17, Fredrik Wiklund17, Pär Stattin18, Jianfeng Xu19, S Lilly Zheng19, Jielin Sun19, Lars J Vatten20, Kristian Hveem20, Merethe Kumle21, Margaret Tucker2, Daniela S Gerhard22, Robert N Hoover2, Joseph F Fraumeni Jr2, David J Hunter4,23, Gilles Thomas2 & Stephen J Chanock2
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 
10-10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
- Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA.
- Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, USA.
- Bioinformed Consulting Services, Gaithersburg, Maryland, USA.
- Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
- Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA.
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
- Centre de Recherche pour les Pathologies Prostatiques (CeRePP), Hôpital Tenon, Assistance Publique–Hôpitaux de Paris, Paris, France.
- Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
- Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA.
- Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
- Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA.
- Division of Epidemiology, Public Health and Primary Care, Imperial College, London, England.
- Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
- Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
- Johns Hopkins Hospital, Baltimore, Maryland, USA.
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
- Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
- Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
- Institute of Community Medicine, University of Tromsø, Tromsø, Norway.
- Office of Cancer Genomics, NCI, NIH, DHHS, Bethesda, Maryland, USA.
- Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Correspondence to: Meredith Yeager1,2 e-mail: yeagerm@mail.nih.gov
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
Multiple loci identified in a genome-wide association study of prostate cancerNature Genetics Letter (01 Mar 2008)
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Nature Genetics Letter (01 May 2007)
Genome-Wide Association Study of Tanning Phenotype in a Population of European AncestryJournal of Investigative Dermatology Original Article
See all 14 matches for Research
