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Nature Genetics 41, 8 - 10 (2009)
doi:10.1038/ng0109-8

Evaluating signatures of sex-specific processes in the human genome

Carlos D Bustamante1 & Sohini Ramachandran2

  1. Carlos D. Bustamante is at the Department of Biological Statistics and Computational Biology, Cornell University, 102 Weill Hall, Ithaca, New York 14850, USA.
  2. Sohini Ramachandran is at the Society of Fellows and Department of Organismic and Evolutionary Biology, Harvard University, 4100 Biological Laboratories, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

Correspondence to: Carlos D Bustamante1 e-mail: cdb28@cornell.edu


Comparing levels of genetic variation between the X chromosome and autosomes can reveal the different demographic histories of males and females of a species. Taking this approach, two new studies report that the effective population sizes of men and women differ, but they disagree as to which sex outnumbered the other.

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