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Nature Genetics 41, 5 - 6 (2009)
doi:10.1038/ng0109-5
Cohort studies and the genetics of complex disease
Teri A Manolio1
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Teri A. Manolio is at the National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
e-mail: manolio@nih.gov
Abstract
Three new studies identify nearly 20 new loci for serum lipid levels using predominantly a prospective cohort study design which also permits extensive and unbiased characterization of environmental exposures. Given the known, strong environmental influences on these traits, investigation of gene-environment interactions should be emphasized in attempts to understand the complete epidemiologic and genetic architecture of these complex traits.
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