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Nature Genetics 40, 1092–1097 (1 September 2008) | doi:10.1038/ng.207

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Kazuki Yasuda , Kazuaki Miyake , Yukio Horikawa , Kazuo Hara , Haruhiko Osawa , Hiroto Furuta , Yushi Hirota , Hiroyuki Mori , Anna Jonsson , Yoshifumi Sato , Kazuya Yamagata , Yoshinori Hinokio , He-Yao Wang , Toshihito Tanahashi , Naoto Nakamura , Yoshitomo Oka , Naoko Iwasaki , Yasuhiko Iwamoto , Yuichiro Yamada , Yutaka Seino , Hiroshi Maegawa , Atsunori Kashiwagi , Jun Takeda , Eiichi Maeda , Hyoung Doo Shin , Young Min Cho , Kyong Soo Park , Hong Kyu Lee , Maggie C Y Ng , Ronald C W Ma , Wing-Yee So , Juliana C N Chan , Valeriya Lyssenko , Tiinamaija Tuomi , Peter Nilsson , Leif Groop , Naoyuki Kamatani , Akihiro Sekine , Yusuke Nakamura , Ken Yamamoto , Teruhiko Yoshida , Katsushi Tokunaga , Mitsuo Itakura , Hideichi Makino , Kishio Nanjo , Takashi Kadowaki & Masato Kasuga

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 |[times]| 10|[minus]|13, odds ratio (OR) = 1.49).