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Letter
Nature Genetics 40, 1130–1135 (1 September 2008) | doi:10.1038/ng.192
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/|[beta]|-catenin signaling
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Abstract
Constitutive Hedgehog (Hh) signaling underlies several human tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma in skin. Intriguingly, superficial BCCs arise as de novo epithelial buds resembling embryonic hair germs, collections of epidermal cells whose development is regulated by canonical Wnt/β-catenin signaling.
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