News and Views
Nature Genetics 40, 1040 - 1041 (2008)
doi:10.1038/ng0908-1040
Hedgehog in Wnterland
- Dennis Roop is Director of the Regenerative Medicine and Stem Cell Biology Program, University of Colorado, Aurora, Colorado 80045, USA.
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Rune Toftgård is in the Department of Biosciences and Nutrition, Karolinska Institute, Huddinge SE-141 57, Sweden.
e-mail: dennis.roop@uchsc.edu
Abstract
Hedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of European descent, basal cell carcinoma (BCC). A new study shows that BCCs strongly resemble embryonic hair follicles and that BCC induction requires active Wnt/
-catenin signaling.
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