Brief Communication abstract
Nature Genetics 40, 1053 - 1055 (2008)
Published online: 30 July 2008 | doi:10.1038/ng.201
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Michael C O'Donovan1, Nicholas Craddock1, Nadine Norton1, Hywel Williams1, Timothy Peirce1, Valentina Moskvina1, Ivan Nikolov1, Marian Hamshere1, Liam Carroll1, Lyudmila Georgieva1, Sarah Dwyer1, Peter Holmans1, Jonathan L Marchini2, Chris C A Spencer2, Bryan Howie2, Hin-Tak Leung3, Annette M Hartmann4, Hans-Jürgen Möller5, Derek W Morris6, YongYong Shi7, GuoYin Feng8, Per Hoffmann9, Peter Propping10, Catalina Vasilescu9, Wolfgang Maier11, Marcella Rietschel12, Stanley Zammit1, Johannes Schumacher13, Emma M Quinn6, Thomas G Schulze13, Nigel M Williams1, Ina Giegling4, Nakao Iwata14,15, Masashi Ikeda14,15, Ariel Darvasi16, Sagiv Shifman16, Lin He7,17, Jubao Duan18,19, Alan R Sanders18,19, Douglas F Levinson20, Pablo V Gejman18,19, Molecular Genetics of Schizophrenia Collaboration21, Sven Cichon9,10, Markus M Nöthen9,10, Michael Gill6, Aiden Corvin6, Dan Rujescu4, George Kirov1 & Michael J Owen1
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 
10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).
- Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
- Department of Statistics, University of Oxford, OX1 3TG, UK.
- Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0XY, UK.
-
Division of Molecular and Clinical Neurobiology, Ludwig-Maximilians-University, Nu
baumstr. 7, 80336 Munich, Germany. -
Department of Psychiatry, Ludwig-Maximilians-University, Nubaumstr. 7, 80336 Munich, Germany.
- Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College Dublin 8, Ireland.
- Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China.
- Shanghai Institute of Mental Health, Shanghai 200030, China.
- Department of Genomics, Life and Brain Center, University of Bonn, Bonn 53105, Germany.
- Institute of Human Genetics, University of Bonn, Bonn 53105, Germany.
- Department of Psychiatry, University of Bonn, Bonn 53105, Germany.
- Central Institute for Mental Health, Division Genetic Epidemiology in Psychiatry, Mannheim 68159, Germany.
- Genetic Basis of Mood and Anxiety Disorders, US National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
- Department of Psychiatry, Fujita Health University School of Medicine, Aichi 470-1192, Japan.
- Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan.
- Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem 91904, Israel.
- Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
- Center for Psychiatric Genetics, Evanston Northwestern Healthcare (ENH), Evanston, Illinois 60201, USA.
- Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA.
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305, USA.
- A full list of authors and affiliations is provided at the end of this paper.
- School of Nursing, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
- The Queensland Centre for Mental Health Research and The Queensland Institute for Medical Research, Wacol, Queensland 4076, Australia.
- Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
- Atlanta Veterans Affairs Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University, Decatur, Georgia 30033, USA.
- Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
- Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.
- Department of Psychiatry, University of California San Francisco, San Francisco, California 94121, USA.
- Departments of Psychiatry, Washington University, St. Louis, Missouri 63108, USA.
- Departments of Genetics, Washington University, St. Louis, Missouri 63108, USA.
Correspondence to: Michael C O'Donovan1 e-mail: wpcmod@cf.ac.uk
Correspondence to: Michael J Owen1 e-mail: wpcmjo@cf.ac.uk
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