Brief Communication abstract
Nature Genetics 40, 1059 - 1061 (2008)
Published online: 1 August 2008 | doi:10.1038/ng.200
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Robert R Graham1,11,12, Chris Cotsapas1,2,12, Leela Davies1, Rachel Hackett1, Christopher J Lessard3,4, Joanlise M Leon5, Noel P Burtt1, Candace Guiducci1, Melissa Parkin1, Casey Gates1, Robert M Plenge1, Timothy W Behrens6, Joan E Wither7, John D Rioux8, Paul R Fortin9, Deborah Cunninghame Graham10, Andrew K Wong10, Timothy J Vyse10, Mark J Daly1,2, David Altshuler1, Kathy L Moser4 & Patrick M Gaffney4
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 
10-12, OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
- Center for Human Genetic Research, Mass General Hospital, 185 Cambridge Street, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA.
- Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
- Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
- Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455, USA.
- Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
- Arthritis Centre of Excellence; Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network; Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada.
- Université de Montréal and the Montreal Heart Institute Research Center, Montreal, Quebec, Canada.
- University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
- Molecular Genetics and Rheumatology Section, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK.
- Present address: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
- These authors contributed equally to this work.
Correspondence to: Patrick M Gaffney4 e-mail: gaffneyp@lupus.omrf.org
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