News and Views
Nature Genetics 40, 932 - 933 (2008)
doi:10.1038/ng0808-932
H19 in the pouch
Marisa S Bartolomei1, Sebastien Vigneau1 & Michael J O'Neill2
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Marisa S. Bartolomei and Sebastien Vigneau are at the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
e-mail: bartolom@mail.med.upenn.edu - Michael J. O'Neill is at the Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA.
Abstract
The linked maternally expressed H19 and paternally expressed Igf2 genes use a CTCF-dependent DNA methylation–sensitive insulator to govern their allele-specific imprinting patterns. Contrary to expectations, a new study shows that the noncoding H19 RNA has a marsupial ortholog and that key features of the locus are similar, indicating that the imprinting regulation of this locus is conserved among therian mammals.
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NEWS AND VIEWS
Genomic imprinting Mice without a fatherNature News and Views (22 Apr 2004)
Marsupials: alternative mammalsNature News and Views (10 Sep 1981)
RESEARCH
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in theriansNature Genetics Article (01 Aug 2008)
Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutationsNature Genetics Letter (01 Aug 2004)
