Brief Communication abstract
Nature Genetics 40, 952 - 954 (2008)
Published online: 29 June 2008 | doi:10.1038/ng.164
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
Michal Pravenec1,2, Paul C Churchill3,11, Monique C Churchill3, Ondrej Viklicky4, Ludmila Kazdova4, Timothy J Aitman5, Enrico Petretto5,6, Norbert Hubner7, Caroline A Wallace5, Heike Zimdahl7, Vaclav Zidek1, Vladimir Landa1, Joseph Dunbar3, Anil Bidani8, Karen Griffin8, Nathan Qi9, Martina Maxova4, Vladimir Kren1,2, Petr Mlejnek1, Jiaming Wang10 & Theodore W Kurtz10
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
- Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.
- Institute of Biology and Medical Genetics, First Medical Faculty and General Teaching Hospital, Charles University, 12800 Prague, Czech Republic.
- Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
- Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
- MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London W12 ONN, UK.
- Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine, Imperial College, London W12 ONN, UK.
- Max Delbruck Center for Molecular Medicine, Berlin-Buch 13125, Germany.
- Department of Internal Medicine, Loyola University and Hines VA Hospital, Maywood, Illinois 60153, USA.
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
- Department of Laboratory Medicine, University of California, San Francisco, California 94107, USA.
- Deceased.
Correspondence to: Theodore W Kurtz10 e-mail: KurtzT@Labmed2.ucsf.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive ratsKidney International Original Article
Expert assessment of exposure to carcinogens in Norway's offshore petroleum industryJournal of Exposure Science and Environmental Epidemiology Article Response
Integrated transcriptional profiling and linkage analysis for identification of genes underlying diseaseNature Genetics Article (01 Mar 2005)
Kidney-specific chromosome transfer in genetic hypertension: The Dahl hypothesis revisitedKidney International Original Article
See all 17 matches for Research
