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Nature Genetics 40, 818–819 (1 July 2008) | doi:10.1038/ng0708-818
A new identity for the elusive intestinal stem cell
Abstract
The intestinal epithelium, the layer of cells coating the surface of the intestinal lumen, performs vital tasks such as the processing and absorption of ingested micronutrients and the release of non-assimilated materials. While executing these functions, intestinal epithelial cells face constant insults, including exposure to digestive enzymes and bile acids and constant mechanical erosion by intestinal contents.
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