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Nature Genetics 40, 817–818 (1 July 2008) | doi:10.1038/ng0708-817

Shedding light on skin cancer

Paul D P Pharoah

Cutaneous melanoma (CM) tends to cluster in families, with a twofold increase in disease risk in those with an affected first-degree relative. The risk associated with an affected second-degree relative is smaller, consistent with a genetic component to disease susceptibility.