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Letter

Nature Genetics 40, 915–920 (1 July 2008) | doi:10.1038/ng.165

Bmi1 is expressed in vivo in intestinal stem cells

Eugenio Sangiorgi & Mario R Capecchi

Bmi1 plays an essential part in the self-renewal of hematopoietic and neural stem cells. To investigate its role in other adult stem cell populations, we generated a mouse expressing a tamoxifen-inducible Cre from the Bmi1 locus.