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Nature Genetics 40, 821 - 822 (2008)
doi:10.1038/ng0708-821
Conflicting evidence on the frequency of ESR1 amplification in breast cancer
Donna G Albertson1
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Donna G. Albertson is at the Cancer Research Institute, Department of Laboratory Medicine and the University of California San Francisco Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, 94143 USA.
e-mail: albertson@cc.ucsf.edu
Abstract
An earlier report of high-frequency ESR1 amplification in breast cancer is now challenged by correspondence from four groups. This discussion of whether or not there is something 'FISHy' about ESR1 amplification highlights the difficulty of validating such observations, leaving the frequency and clinical significance of ESR1 amplification in breast cancer an open question.
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