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Letter
Nature Genetics 40, 794–799 (1 June 2008) | doi:10.1038/ng.126
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
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Abstract
According to the prevailing view, mammalian X chromosomes are enriched in spermatogenesis genes expressed before meiosis and deficient in spermatogenesis genes expressed after meiosis. The paucity of postmeiotic genes on the X chromosome has been interpreted as a consequence of meiotic sex chromosome inactivation (MSCI)—the complete silencing of genes on the XY bivalent at meiotic prophase.
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