News and Views
Nature Genetics 40, 691 - 692 (2008)
doi:10.1038/ng0608-691
The hippocratic finger points the blame at PGE2
Kenneth G Coggins1, Thomas M Coffman2 & Beverly H Koller3
- Kenneth G. Coggins is in the Department of Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA.
- Thomas M. Coffman is in the Division of Nephrology, Department of Medicine, Duke University, North Carolina 27710, USA.
- Beverly H. Koller is in the Departments of Genetics and Medicine, Division of Pulmonary and Critical Care, University of North Carolina at Chapel Hill, North Carolina 27599, USA. e-mail: treawouns@aol.com
Abstract
Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.
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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathyNature Genetics Letter (01 Jun 2008)
