1. Jo Peters is at the Medical Research Council Harwell, Mammalian Genetics Unit, Oxfordshire OX11 0RD, UK. e-mail: j.peters@har.mrc.ac.uk

Abstract

A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.

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