Brief Communication abstract

Nature Genetics 40, 707 - 709 (2008)
Published online: 25 May 2008 | doi:10.1038/ng.151

Multiple ADH genes are associated with upper aerodigestive cancers

Mia Hashibe1, James D McKay1, Maria Paula Curado1,2, Jose Carlos Oliveira2, Sergio Koifman3, Rosalina Koifman3, David Zaridze4, Oxana Shangina4, Victor Wünsch-Filho5, Jose Eluf-Neto5, Jose Eduardo Levi5, Elena Matos6, Pagona Lagiou7, Areti Lagiou7, Simone Benhamou8, Christine Bouchardy9, Neonilia Szeszenia-Dabrowska10, Ana Menezes11, Marinel Mór Dall'Agnol11, Franco Merletti12, Lorenzo Richiardi12, Leticia Fernandez13, Juan Lence13, Renato Talamini14, Luigi Barzan15, Dana Mates16, Ioan Nicolae Mates17, Kristina Kjaerheim18, Gary J Macfarlane19, Tatiana V Macfarlane19, Lorenzo Simonato20, Cristina Canova20, Ivana Holcátová21, Antonio Agudo22, Xavier Castellsagué22, Ray Lowry23, Vladimir Janout24, Helena Kollarova24, David I Conway25, Patricia A McKinney26,27, Ariana Znaor28, Eleonora Fabianova29, Vladimir Bencko21, Jolanta Lissowska30, Amelie Chabrier1, Rayjean J Hung1,31, Valerie Gaborieau1, Paolo Boffetta1 & Paul Brennan1

Top

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10- 10 and 10- 9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

Top
  1. International Agency for Research on Cancer, Lyon, France.
  2. Hospital Araujo Jorge, Goiania, and Populational Cancer Register of Goiania, Brazil.
  3. Escola Nacional de Suade Publica, Rio de Janeiro, Brazil.
  4. Cancer Research Centre, Moscow, Russia.
  5. Universidade de Sao Paulo, Sao Paulo, Brazil.
  6. Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina.
  7. University of Athens School of Medicine, Athens, Greece.
  8. Institut National de la Santé et de la Recherche Médicale U794, Evry, France.
  9. Geneva Cancer Registry, Geneva, Switzerland.
  10. Institute of Occupational Medicine, Lodz, Poland.
  11. Universidade Federal de Pelotas, Pelotas, Brazil.
  12. Unit of Cancer Epidemiology, CeRMS and University of Turin, Turin, Italy.
  13. Institute of Oncology and Radiobiology, Havana, Cuba.
  14. Aviano Cancer Centre, Aviano, Italy.
  15. General Hospital of Pordenone, Pordenone, Italy.
  16. Institute of Public Health, Bucharest, Romania.
  17. University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
  18. Cancer Registry of Norway, Oslo, Norway.
  19. University of Aberdeen School of Medicine, Aberdeen, UK.
  20. University of Padua, Padova, Italy.
  21. Institute of Hygiene and Epidemiology, Prague, Czech Republic.
  22. Institut Català d'Oncologia, Barcelona, Spain.
  23. University of Newcastle Dental School, Newcastle, UK.
  24. Palacky University, Olomouc, Czech Republic.
  25. University of Glasgow Dental School, Glasgow, Scotland.
  26. University of Leeds Centre for Epidemiology and Biostatistics, Leeds, UK.
  27. NHS National Services Scotland, Information Services Division, Edinburgh, Scotland.
  28. Croatian National Cancer Registry, Zagreb, Croatia.
  29. Specialized State Health Institute, Banská Bystrica, Slovakia.
  30. The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
  31. School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA.

Correspondence to: Paul Brennan1 e-mail: Brennan@iarc.fr



Extra navigation

Subscribe to Nature Genetics

Subscribe

Search PubMed for

Open Innovation Challenges

naturejobs

More science jobs
Post a job for free

ADVERTISEMENT