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Nature Genetics 40, 495–496 (1 May 2008) | doi:10.1038/ng0508-495

Salt wasting and blood pressure

Olivier Devuyst

Every day, an individual's kidneys filter 180 l of plasma and reabsorb more than 99% of the filtered sodium, corresponding to over 1 kg of salt. This massive reabsorption of NaCl results from transport mechanisms operating in the epithelial cells lining specialized tubular segments.