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Nature Genetics 40, 494–495 (1 May 2008) | doi:10.1038/ng0508-494

Coevolution in the tumor microenvironment

Robert A Weinberg

Cancer research over the past three decades has focused on the neoplastic cells within tumors. However, in recent years, tumors have come to be understood to function as complex tissues in which numerous recruited host cells also play critical roles.