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Letter

Nature Genetics 40, 650–655 (1 May 2008) | doi:10.1038/ng.117

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

Wen Qiu , Min Hu , Anita Sridhar , Ken Opeskin , Stephen Fox , Michail Shipitsin , Melanie Trivett , Ella R Thompson , Manasa Ramakrishna , Kylie L Gorringe , Kornelia Polyak , Izhak Haviv & Ian G Campbell

There is increasing evidence showing that the stromal cells surrounding cancer epithelial cells, rather than being passive bystanders, might have a role in modifying tumor outgrowth. The molecular basis of this aspect of carcinoma etiology is controversial.