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Letter

Nature Genetics 40, 616–622 (1 May 2008) | doi:10.1038/ng.109

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

Christopher I Amos , Xifeng Wu , Peter Broderick , Ivan P Gorlov , Jian Gu , Timothy Eisen , Qiong Dong , Qing Zhang , Xiangjun Gu , Jayaram Vijayakrishnan , Kate Sullivan , Athena Matakidou , Yufei Wang , Gordon Mills , Kimberly Doheny , Ya-Yu Tsai , Wei Vivien Chen , Sanjay Shete , Margaret R Spitz & Richard S Houlston

To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas.