Figure 4 - Chromosome 16 haplotype analysis.

From the following article

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility

Jacques Behmoaras, Gurjeet Bhangal, Jennifer Smith, Kylie McDonald, Brenda Mutch, Ping Chin Lai, Jan Domin, Laurence Game, Alan Salama, Brian M Foxwell, Charles D Pusey, H Terence Cook & Timothy J Aitman

Nature Genetics 40, 553 - 559 (2008) Published online: 28 April 2008

doi:10.1038/ng.137

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(a) Crgn2 genetic map. High and low macrophage infiltration denote, respectively, strains with macrophage infiltration that is or is not significantly greater than that in the LEW strain. Numbers denote classification of alleles: 1, LEW; 2, WKY; 3 and 4, other alleles. Genetic locations of other significantly differentially expressed genes in the overall Crgn2 congenic interval are also indicated. The boxed area corresponds to microsatellite markers (D16Rat78 and D16Rat82) mapping to the peak of linkage in Crgn2. Genetic distances are indicated in cM. (b) Fine haplotype mapping delineates a maximal 430-kb region of haplotypic identity segregating with macrophage infiltration. Physical location of the markers is indicated in Mbp. The Jund C/T promoter polymorphism showed the same haplotype as D16Got22 and Jund1.

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