News and Views
Nature Genetics 40, 495 - 496 (2008)
doi:10.1038/ng0508-495
Salt wasting and blood pressure
Olivier Devuyst1
- Olivier Devuyst is at the Division of Nephrology, Université catholique de Louvain Medical School, B-1200 Brussels, Belgium. e-mail: Olivier.Devuyst@uclouvain.be
Abstract
Recessive loss-of-function mutations in genes involved in renal NaCl handling cause rare diseases characterized by salt wasting and reduced blood pressure of variable severity. A new study shows that the carrier state for rare inactivating mutations in three genes involved in NaCl transport in the kidney is associated with a significant blood pressure reduction and a reduced risk of hypertension in the general population.
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