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Nature Genetics 40, 494 - 495 (2008)
doi:10.1038/ng0508-494
Coevolution in the tumor microenvironment
Robert A Weinberg1
- Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology Department of Biology, Cambridge, Massachusetts 02142, USA. e-mail: weinberg@wi.mit.edu
Abstract
The progression of carcinomas to high-grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma undergo genetic alterations during this progression, a new study now provides evidence that strongly contradicts this theory of stromal cell coevolution.
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