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Nature Genetics 40, 380–382 (1 April 2008) | doi:10.1038/ng0408-380

Adding pathogens by genomic subtraction

Laura MacConaill & Matthew Meyerson

Infectious pathogens are surmised to initiate many complex human diseases, but finding causative organisms has often proven difficult. Now, two independent studies report the application of high-throughput pyrosequencing to identify viruses in diseased human tissue.