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Letter

Nature Genetics 40, 466–470 (1 April 2008) | doi:10.1038/ng.116

Transient-mediated fate determination in a transcriptional circuit of HIV

Leor S Weinberger , Roy D Dar & Michael L Simpson

Steady-state behavior and bistability have been proposed as mechanisms for decision making in gene circuits. However, transient gene expression has also been proposed to control cell fate, with the decision arbitrated by the duration of a transient gene expression pulse.