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Nature Genetics 40, 382 - 383 (2008)
doi:10.1038/ng0408-382
HIV-1 positive feedback and lytic fate
Iftach Nachman1 & Sharad Ramanathan1
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Sharad Ramanathan and Iftach Nachman are at the Faculty of Arts and Sciences Center for System Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
e-mail: sharad@post.harvard.edu
Abstract
The HIV viral lifecycle includes infection of a host cell, followed by a critical decision between latency and lysis. A new study suggests that positive feedback in the HIV-1 promoter, involving Tat protein and gene expression, has a role in this critical choice of fate.
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