Brief Communication abstract
Nature Genetics 40, 390 - 391 (2008)
Published online: 23 March 2008 | doi:10.1038/ng.114
Evolutionary plasticity of genetic interaction networks
Julia Tischler1, Ben Lehner2 & Andrew G Fraser1
Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
- The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
- European Molecular Biology Laboratory-Center for Genomic Regulation Systems Biology Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, c/ Dr Aiguader 88, Barcelona 08003, Spain.
Correspondence to: Andrew G Fraser1 e-mail: agf@sanger.ac.uk
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