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Letter

Nature Genetics 40, 310–315 (1 March 2008) | doi:10.1038/ng.91

Multiple loci identified in a genome-wide association study of prostate cancer

Gilles Thomas , Kevin B Jacobs , Meredith Yeager , Peter Kraft , Sholom Wacholder , Nick Orr , Kai Yu , Nilanjan Chatterjee , Robert Welch , Amy Hutchinson , Andrew Crenshaw , Geraldine Cancel-Tassin , Brian J Staats , Zhaoming Wang , Jesus Gonzalez-Bosquet , Jun Fang , Xiang Deng , Sonja I Berndt , Eugenia E Calle , Heather Spencer Feigelson , Michael J Thun , Carmen Rodriguez , Demetrius Albanes , Jarmo Virtamo , Stephanie Weinstein , Fredrick R Schumacher , Edward Giovannucci , Walter C Willett , Olivier Cussenot , Antoine Valeri , Gerald L Andriole , E David Crawford , Margaret Tucker , Daniela S Gerhard , Joseph F Fraumeni , Robert Hoover , Richard B Hayes , David J Hunter & Stephen J Chanock

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial prospective study—by testing 26,958 SNPs in four independent studies (total of 3,941 cases and 3,964 controls). In the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P |[minus]|10).