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Brief Communication

Nature Genetics 40, 281–283 (1 March 2008) | doi:10.1038/ng.89

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

Julius Gudmundsson , Patrick Sulem , Thorunn Rafnar , Jon T Bergthorsson , Andrei Manolescu , Daniel Gudbjartsson , Bjarni A Agnarsson , Asgeir Sigurdsson , Kristrun R Benediktsdottir , Thorarinn Blondal , Margret Jakobsdottir , Simon N Stacey , Jelena Kostic , Kari T Kristinsson , Birgitta Birgisdottir , Shyamali Ghosh , Droplaug N Magnusdottir , Steinunn Thorlacius , Gudmar Thorleifsson , S Lilly Zheng , Jielin Sun , Bao-Li Chang , J Bradford Elmore , Joan P Breyer , Kate M McReynolds , Kevin M Bradley , Brian L Yaspan , Fredrik Wiklund , Par Stattin , Sara Lindstr|[ouml]|m , Hans-Olov Adami , Shannon K McDonnell , Daniel J Schaid , Julie M Cunningham , Liang Wang , James R Cerhan , Jennifer L St Sauver , Sara D Isaacs , Kathleen E Wiley , Alan W Partin , Patrick C Walsh , Sonia Polo , Manuel Ruiz-Echarri , Sebastian Navarrete , Fernando Fuertes , Berta Saez , Javier Godino , Philip C Weijerman , Dorine W Swinkels , Katja K Aben , J Alfred Witjes , Brian K Suarez , Brian T Helfand , Michael L Frigge , Kristleifur Kristjansson , Carole Ober , Eirikur Jonsson , Gudmundur V Einarsson , Jianfeng Xu , Henrik Gronberg , Jeffrey R Smith , Stephen N Thibodeau , William B Isaacs , William J Catalona , Jose I Mayordomo , Lambertus A Kiemeney , Rosa B Barkardottir , Jeffrey R Gulcher , Unnur Thorsteinsdottir , Augustine Kong & Kari Stefansson

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 |[times]| 10|[minus]|13 and 7.7 |[times]| 10|[minus]|9, respectively).