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Letter
Nature Genetics 40, 362–366 (1 March 2008) | doi:10.1038/ng.2007.64
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint
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Abstract
In both yeast and mammals, uncapped telomeres activate the DNA damage response (DDR) and undergo end-to-end fusion. Previous work has shown that the Drosophila HOAP protein, encoded by the caravaggio (cav) gene, is required to prevent telomeric fusions.
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