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Letter
Nature Genetics 40, 356–361 (1 March 2008) | doi:10.1038/ng.2007.50
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
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Abstract
During electron transport, the mitochondrion generates ATP and reactive oxygen species (ROS), a group of partially reduced and highly reactive metabolites of oxygen. In this in vivo genetic analysis in Drosophila melanogaster, we establish that disruption of complex I of the mitochondrial electron transport chain specifically retards the cell cycle during the G1-S transition.
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