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Letter

Nature Genetics 40, 335–339 (1 March 2008) | doi:10.1038/ng.100

Disruption of P2RY5, an orphan G protein|[ndash]|coupled receptor, underlies autosomal recessive woolly hair

Yutaka Shimomura , Muhammad Wajid , Yoshiyuki Ishii , Lawrence Shapiro , Lynn Petukhova , Derek Gordon & Angela M Christiano

The genetic determinants of hair texture in humans are largely unknown. Several human syndromes exist in which woolly hair comprises a part of the phenotype; however, simple autosomal recessive inheritance of isolated woolly hair has only rarely been reported.