Letter abstract
Nature Genetics 40, 316 - 321 (2008)
Published online: 10 February 2008 | doi:10.1038/ng.90
Multiple newly identified loci associated with prostate cancer susceptibility
Rosalind A Eeles1,2, Zsofia Kote-Jarai1,14, Graham G Giles3,4,14, Ali Amin Al Olama5,14, Michelle Guy1,14, Sarah K Jugurnauth1, Shani Mulholland1, Daniel A Leongamornlert1, Stephen M Edwards1, Jonathan Morrison5, Helen I Field6, Melissa C Southey7, Gianluca Severi3,4, Jenny L Donovan8, Freddie C Hamdy9, David P Dearnaley1,2, Kenneth R Muir10, Charmaine Smith3, Melisa Bagnato3, Audrey T Ardern-Jones2, Amanda L Hall1,2, Lynne T O'Brien1, Beatrice N Gehr-Swain1,2, Rosemary A Wilkinson1, Angie Cox9, Sarah Lewis8, Paul M Brown11, Sameer G Jhavar1, Malgorzata Tymrakiewicz1, Artitaya Lophatananon10, Sarah L Bryant1, The UK Genetic Prostate Cancer Study Collaborators13, British Association of Urological Surgeons' Section of Oncology13, The UK ProtecT Study Collaborators13, Alan Horwich1,2, Robert A Huddart1,2, Vincent S Khoo2,1, Christopher C Parker1,2, Christopher J Woodhouse2, Alan Thompson2, Tim Christmas2, Chris Ogden2, Cyril Fisher2, Charles Jamieson2, Colin S Cooper1, Dallas R English4, John L Hopper4, David E Neal11,12,14 & Douglas F Easton5
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at 
60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 
10-8 to P = 8.7 10-29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.
- The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
- The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, and Fulham Road, London SW3 6JJ, UK.
- Cancer Epidemiology Centre, The Cancer Council Victoria, 1 Rathdowne Street, Carlton VIC 3053, Australia.
- Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton VIC 3053, Australia.
- Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
- Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
- Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Grattan Street, Parkville VIC 3052, Australia.
- Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK.
- Academic Urology Unit, University of Sheffield, Sheffield, S10 2JF, UK.
- University of Nottingham Medical School, Queens Medical Centre, Nottingham, NG7 2UH, UK.
- Surgical Oncology (Uro-Oncology S4), Departments of Oncology and Surgery, University of Cambridge, Box 279, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
- Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
- A full list of authors is provided in the Supplementary Note online.
- These authors contributed equally to this work.
Correspondence to: Rosalind A Eeles1,2 e-mail: rosalind.eeles@icr.ac.uk
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