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Nature Genetics 40, 134–135 (1 February 2008) | doi:10.1038/ng0208-134
Two ways to make an mtDNA bottleneck
Abstract
Rapid changes in mitochondrial DNA allele frequency between generations have been explained by an 'mtDNA bottleneck' in the germ line, and it has recently been proposed that mtDNA aggregates, or nucleoids, drive such a bottleneck. Now, a new study finds a sharp reduction in mtDNA content in the germ line and suggests that such reduction alone may account for the bottleneck effect. At conception, we receive about 100,000 copies of mitochondrial DNA (mtDNA) that populate the egg. Intriguingly, all these copies are usually identical.
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