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Letter

Nature Genetics 40, 204–210 (1 February 2008) | doi:10.1038/ng.81

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

John B Harley , Marta E Alarc|[oacute]|n-Riquelme , Lindsey A Criswell , Chaim O Jacob , Robert P Kimberly , Kathy L Moser , Betty P Tsao , Timothy J Vyse & Carl D Langefeld

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (|[lambda]|S = |[sim]|30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls, and we genotyped consistently associated SNPs in two additional independent sample sets totaling 1,846 affected women and 1,825 controls.