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Letter

Nature Genetics 40, 198–203 (1 February 2008) | doi:10.1038/ng.74

Common variants in the GDF5-UQCC region are associated with variation in human height

Serena Sanna , Anne U Jackson , Ramaiah Nagaraja , Cristen J Willer , Wei-Min Chen , Lori L Bonnycastle , Haiqing Shen , Nicholas Timpson , Guillaume Lettre , Gianluca Usala , Peter S Chines , Heather M Stringham , Laura J Scott , Mariano Dei , Sandra Lai , Giuseppe Albai , Laura Crisponi , Silvia Naitza , Kimberly F Doheny , Elizabeth W Pugh , Yoav Ben-Shlomo , Shah Ebrahim , Debbie A Lawlor , Richard N Bergman , Richard M Watanabe , Manuela Uda , Jaakko Tuomilehto , Josef Coresh , Joel N Hirschhorn , Alan R Shuldiner , David Schlessinger , Francis S Collins , George Davey Smith , Eric Boerwinkle , Antonio Cao , Michael Boehnke , Gon|[ccedil]|alo R Abecasis & Karen L Mohlke

Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population.